Bringing chemical analysis out of the lab to where it matters most
Guardion is making analytical instruments, chemical detectors, and radiation detectors more sensitive, portable, and easier to scale with nanomaterial based ion detectors.
Guardion brings critical chemical analysis tools out of the lab where they are needed
The global push towards point-of-care medical diagnostics, real-time environmental monitoring, and rapid biological threat detection necessitates innovative analytical tools like portable mass spectrometers. The current generation of these tools, burdened by their size, high operational voltages, and reliance on cumbersome pumping systems, can not be deployed in the field, on manufacturing lines, or reactor lines. This prevents rapid medical diagnostics, efficient environmental monitoring, higher manufacturing yield, and timely detection of threats, representing a market pain with a cost implication running into billions annually.
Guardion introduces a revolutionary charge sensor enhancing the portability, ruggedness, and sensitivity of analytical tools, transforming them from lab-bound equipment to versatile field-deployable instruments.
Our 2D material technology enables a million times amplification with a 10,000-fold reduction in voltage and eliminates the need for bulky vacuum systems and high-voltage components. This innovation addresses a significant market need, democratizing the use of mass spectrometry across various fields and catalyzing new applications in diagnostics and monitoring.
01
REDUCE SIZE, WEIGHT, and POWER
Eliminate high-voltage components and minimize instrument mass and power needs by eliminating pumping requirements.
02
INCREASE DURABILITY
Operate in high-pressure conditions and improve reliability by removing failure modes tied to vacuum systems.
03
REDUNDANCY
Multiple addressable amplifiers in less volume and weight than a single electron multiplier.
ABOUT
Our technology transforms high sensitivity chemical analysis tools, like mass spectrometers from bench top tools stuck in the lab to field portable instruments. This enables the future of real-time chemical analysis in critical settings like healthcare, environmental monitoring, and defense.
1,000,000x Amplification
10,000x less voltage
Works in open air
Wafer Scale
By replacing electron multipliers with a 2D material-based charge sensor, we achieve ultra-sensitive detection without high-voltage or vacuum requirements. This leap in portability and performance opens new possibilities for global health, security, and industrial innovation.
MARKET
The $15B instrumentation market, which includes mass spectrometry, RGAs, leak detectors, and radiation sensors, will be transformed by our technology. We will first target the $6B mass spectrometry market, projected to grow to $15B by 2030 to meet emerging needs in manufacturing, environmental monitoring, and healthcare. The underlying detector market, currently at $750M, is expected to reach $1.1B by 2030.
Our business model centers on wafer-scale detector technology with low production costs (under $100) and high margins (selling detectors at $2,000–$5,000). Early revenue comes from partnerships with established instrument manufacturers, leveraging
Guardion’s detector as a upgrade to existing instrumentation. This approach validates the technology and builds credibility. Subsequently, we plan to develop our own portable instruments at $30,000–$50,000, positioning the company for broad market adoption or a strategic acquisition common in the sector. Our focus will be on inline chemical analysis (bioreactors) , point-of-care diagnostics, and biological and chemical threat detection markets.
TEAM
Guardion’s team brings deep expertise in material science, nanomaterials, quantum, and sensing.
Daniel Esposito
CEO, Nanomaterials Manufacturing, Business Development, $2M+ in Awards, Co-inventor on enabling tech. PI for Air Force, NASA, and NSF projects. Lead team in wins at MassChallenge, Techstars, NASA Entrepreneurship Challenge, and CASIS Technology in Space Prize.
Dr. Daniel Cohen
Lead Scientist 15+ Years novel optoelectronic and electrochemical devices. Multiple patents in solar and quantum dot materials. Co-inventor on enabling tech (QD Vision, Konarka)
Dr. Swastik Kar
2D Materials Expert 100+ publications and is a co-inventor on 10 patents. Director of Northeastern’s Experiential Quantum Advancement Laboratories and Professor of Physics.
Funding and Awards
NASA SBIR Phase I & Phase II Awardee
Guardion is developing a groundbreaking low-voltage, low-power ion detector for mass spectrometers that operates under ambient pressure. This innovation eliminates the need for high-voltage electron multipliers and associated hardware, significantly reducing size, weight, and power (SWaP) requirements while improving durability and reliability in challenging environments. The technology will enable NASA to pursue more ambitious planetary exploration missions by enhancing analytical capability and eliminating common failure modes.
NASA SMD Entrepreneurs Challenge Winner
Guardion was a winner of the NASA Science Mission Directorate's inaugural Entrepreneur’s Challenge for advanced mass spectrometry for detection of the elements necessary for life and other science applications by using instrumentation beyond what is currently available in terms of low-power and low-mass and using cutting edge materials or components to innovate in sampling technology and processes
Air Force SBIR Phase I Awardee
Enhanced Air Force Chemical Detection for Human Performance, CBRN, Environmental Monitoring, and Manufacturing.
MassVentures START Stage 1 Winner
We’re thrilled to announce that we’ve been named a Stage 1 winner of the MassVentures START grant. This recognition highlights our commitment to pioneering solutions and drives us forward in our mission to innovate and grow in Massachusetts and beyond..
Materials Research Society IMatSci Innovative Showcase Winner
MRS iMatSci Innovations Showcase, a Materials Research Society program that highlights groundbreaking materials-based technologies.
Techstars Autnomous Business
The Air Force-sponsored Techstars Autonomous Accelerator, a prestigious program that connects innovative startups with Air Force resources to advance cutting-edge autonomous technologies.
MassChallenge accelerator Gold Winner
Awarded the MassChallenge Gold Prize, a prestigious honor recognizing our innovation, impact, and market potential.
Winner of the Technology in Space Prize, Center for the Advancement of Science in Space
Guardion was awarded the CASIS/Boeing Technology in space prize for a project evaluating the role of microgravity in the synthesis of 2D-materials.
NSF SBIR Phase II: Ultrasensitive ion-sensors for wide range pressure measurement
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is enabling increased throughput and quality in semiconductor, chemical and biochemical manufacturing. The ability to monitor pressure from atmosphere to ultra-high vacuum is a critical need for these industries.
MIT Engine Blueprint Team
We’ve been selected as a MIT Engine Blueprint Team, a prestigious early-stage program founded by MIT to help ‘tough tech’ startups bridge the gap between discovery and commercialization. Through this initiative, we gain vital mentorship, resources, and support to advance our technology and bring transformative solutions to market.
NSF National Level ICORPS Team
Guardion was selected the NSF National Level I-Corps program, a prestigious initiative designed to help researchers and startups quickly commercialize high-potential technologies.
06
CONTACT
Let’s work together.
(603) 769-7265
dan@guardiontech.com
151 S Bedford St
Burlington, MA 01803
© Guardion, Inc. 2025